Adrenaline Hydrochloride Injection
Generic Name: Adrenaline Hydrochloride
Product Name: Adrenaline Hydrochloride Injection
Packaging: 1ml x 10 vials
- Initial dose in the case of a cardiac arrest should be 1mg (that is 10mL of 1:10,000) intravenously.
- This should be injected more slowly in elderly patients as they are more susceptible to the effects of adrenaline.
- The preferred route is via a central venous catheter.
- This dose (1mg) can be administered 3-5 minutely throughout cardiopulmonary resuscitation (CPR).
- Children should receive 0.1mL/kg (0.01mg/kg) repeated 5 minutely as required.
- To maintian blood pressure after the return of a spontaneous pulse, bolus doses or continuous infusions may be useful.
Adrenaline stimulates certain chemical receptors in the body resulting in constriction of blood vessels, increased blood pressure, fast pulse, widening of the space inside the windpipe, higher blood sugar levels, lower blood potassium levels and antihistamine effects (eg: Stops the overproduction of mucous). It is useful in cardiac arrests because it stimulates the heart. Adrenaline acts rapidly and for a very short time, so often more than one dose is necessary.
How should I use Adrenaline Hydrochloride Injection?
Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended. Adrenaline Hydrochloride Injection is injected into the muscle of your outer thigh. In an emergency, this injection can be given through your clothing.
Acute Asthma (Parenteral)
Adult: As 1:1,000 aqueous solution: 0.3-0.5 ml (300-500 mcg). Dose may be given via IM or SC inj.
Child: As 1:1,000 aqueous solution: 0.01 ml/kg (10 mcg/kg). Max: 0.5 ml (500 mcg). Dose may be given via IM or SC inj.
Advanced Cardiac Life Support (Intravenous)
Adult: Initially, 1 mg (10 mL of a 1:10,000 solution), may repeat as often as every 2-3 minutes throughout the resuscitation process. May also be given via intraosseous route at the same dosage. For endotracheal doses: 2-3 times of the IV dose.
Child: Initially, 10 mcg/kg, may repeat as often as every 2-3 minutes throughout the resuscitation process. Endotracheal doses: 100 mcg/kg. Intraosseous doses are the same as IV doses. Max Dosage: Intraosseous doses for adults and children are the same as IV doses.
Max Dosage: Intraosseous doses for adults and children are the same as IV doses.
Anaphylactic shock (Intravenous)
Adult: 0.5 mg (5 mL of a 1:10,000 solution) given at a slow rate of 100 mcg/minute, stopping when a response is achieved.
Child: 10 mcg/kg. If autoinjectors are used, doses are based on body wt: 15-30 kg: 150 mcg and >30 kg: 300 mcg.
Anaphylactic shock (Intramuscular)
Adult: As 1:1,000 solution: 500 mcg (0.5 ml), repeat every 5 minutes as needed until improvement occurs. For emergency self-admin (e.g. via autoinjector): A dose of 300 mcg (0.3 ml) may be used.
Child: Dose depends on age and weight. Usual dose: 10 mcg/kg.
Common side effects
- Fast pulse;
- Shortness of breath;
- Cold hands and feet;
- Pale skin colour;
- Nausea and vomiting;
- Insomnia; and
- Flushing (redness in the skin, particularly in the face).
Uncommon side effects
- Disorientation; and
- Changes in memory, mood and personality.
Seek emergency medical attention after any use of Adrenaline Hydrochloride Injection to treat a severe allergic reaction. The effects of Adrenaline Hydrochloride Injection may wear off after 10 or 20 minutes. You will need to receive further treatment and observation. Do not use Adrenaline Hydrochloride Injection injection if it has changed colors or has particles in it, or if the expiration date on the label has passed. Call your pharmacist for a new prescription. Store at room temperature away from moisture, heat, and light. Do not refrigerate or freeze this medication, and do not store it in a car.