Saxenda $250

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Saxenda® Injection Pen

Most Effective Weight Loss Shot

You have tried for years. Countless diets. Short-term exercise fads. Endless frustration. It’s no longer about finding a quick fix—it’s about focusing on your ongoing weight loss. Reducing your waistline isn’t the only impact of weight loss. Taking off weight and keeping it off may help improve conditions such as high blood pressure and high cholesterol levels.

What Saxenda® is?

Saxenda® is a weight loss medicine that contains the active ingredient liraglutide. It is similar to a naturally occurring hormone called GLP-1 that is released from the intestine after a meal. . Saxenda® is an injection that is used once a day.

Saxenda® is used for weight loss, in addition to diet and exercise, in adults aged 18 years and above who have:

  • a BMI greater than or equal to 30 (obese) or
  • a BMI greater than or equal to 27 and less than 30 (overweight) and weight related health problems (such as diabetes, high blood pressure, abnormal levels of fats in the blood or breathing problems during sleep, called ‘obstructive sleep apnea’).

Saxenda® works by acting on receptors in the brain that control your appetite, causing you to feel fuller and less hungry. This may help you eat less food and reduce your body weight. It is an FDA-approved, prescription injectable medicine that may help obese adults to lose weight and keep it off.  NO worry, Saxenda® is not addictive.

Saxenda (or Liraglutide which is another name for this medication) sits on this receptor and causes changes to very important hormones involved in regulating body weight: insulin, leptin and glucagon.

Many studies have shown that patients using Saxenda lose significant amounts of weight over several weeks (usually around 10% body fat). ​That means that using this medication might help you lose up to 20 pounds if you weighed 200 pounds.

At first, it doesn’t sound very good, right?  but it’s actually quite impressive if you consider that this weight loss is achieved generally without any other therapies added.

And that’s where things get interesting.

If you have an understanding of weight loss and how hormones influence your weight, you can benefit even more from using this medication.

Why? Because it can safely be combined with other therapies that also increase your weight loss efforts and together this can result in dramatic weight loss. (eg: work out, low carb diet)

 

5 Ways Saxenda Helps Boost Weight Loss

​Saxenda is a medication that falls into the “GLP-1 ” agonist class of drugs. ( GLP-1 stands for Glucagon like peptide 1 )

Saxenda (or Liraglutide which is another name for this medication) , sits on this receptor and causes changes to very important hormones involved in regulating body weight: insulin, leptin and glucagon.

Liraglutide was originally developed to treat type II diabetes because it can help reduce insulin resistance, but was soon found to have a dramatic effect on weight.

Because of this the makers of Liraglutide (or Victoza as it is called if used to treat type II diabetes) came out with new name (saxenda) which is now FDA approved for weight loss.

Simply taking Saxenda will help you lose some weight by itself (definitely), but it won’t get you back to the ideal weight by itself (you will have to workout and low card diet)

I will talk about the downside of using Saxenda below, but for now let’s talk about HOW it works :

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#1. Reduces Leptin Resistance

Leptin is probably one of the more important hormones involved in weight management and it’s also probably the most neglected.

Studies have shown that Liraglutide (Saxenda)  does two important things related to Leptin and Leptin resistance:

 

  • Reduces existing leptin resistance – meaning it helps change the biochemistry of the body to ALLOW for weight loss to occur.
  • Attenuates (or reduces) the rise in leptin resistance once you start losing weight – meaning it helps you keep off the weight that you are losing

 

This changes the biochemistry in your body and helps to naturally reduce your appetite, increase your metabolism and increase fat burning capacity.

This change alone is probably why Saxenda is so effective for weight loss, but it has more benefits beyond this. ​

 

  • Bottom line: Saxenda helps reduce leptin levels and helps treat leptin resistance. Leptin is responsible for weight loss resistance. 

 

#2. Improves Insulin Sensitivity

Saxenda also helps reduce insulin resistance.

Insulin resistance is the root cause of type II diabetes mellitus and insulin is responsible for the majority of the negative consequences associated with that disease.

What you may not realize is that insulin resistance is incredibly common in the world. It’s estimated that up to 50% of the population has some degree of insulin resistance and, by lab testing, show signs of diabetes or pre-diabetes.

Insulin is also a very important hormone involved in the weight loss equation. When insulin levels are high, it’s almost impossible for your body to burn fat.

Why? Because insulin blocks the action of an enzyme called hormone sensitive lipase.

This hormone is responsible for turning on “fat burning mode” and in the presence of high insulin, this enzyme is always on the “off” setting. This is obviously a big problem if you are trying to lose weight.

In addition to preventing your body from burning fat as an energy source insulin also has the added problem of promoting fat storage.  This means that if you consume calories (from any source) these calories will be stored as fat in the presence of high levels of circulating insulin.

This is true even if you are consuming a low calorie diet.

Insulin doesn’t care how many calories you are consuming, it cares about storing whatever you eat as fat. ​

​So how does Saxenda work?

Saxenda helps sensitize the body to insulin levels and helps to lower blood glucose levels in the process.

Using Saxenda (especially when combined with the right diet, exercise and supplements) can dramatically reduce fasting insulin levels and also fasting blood glucose levels. It also significantly help to improve other hormones in the body.

For instance, insulin resistance can cause low testosterone (in men) and high testosterone (in women). When you treat insulin levels these hormone imbalances tend to improve which will naturally result in weight loss and a reduction in symptoms associated with THOSE imbalances.

 

  • Bottom line: GLP-1 agonists help reduce insulin resistance and lower blood sugar. This activates hormone sensitive lipase and results in more fat burning over time. 

 

#3. Acts as a Glucagon Suppressant

Glucagon is another hormone which is important for weight loss, but one that is less understood than insulin or leptin.

Over the next 5-10 years we will see a lot more research done on this hormone and how it relates to weight loss, but for now we can talk about what we already know.

Glucagon is basically the exact opposite of insulin – in terms of how it alters blood glucose levels. Insulin lowers blood sugar levels while glucagon helps increase blood sugar levels.

How does this relate to weight loss?

It turns out that in order to help burn fat in the body, your body must naturally deplete liver glycogen stores and have low enough insulin levels to promote hormone sensitive lipase to activate.

In states that cause insulin resistance there is also some degree of hyperglucagonemia – and this states promotes consistently high levels of glucose.

High glucagon also seems to interfere with normal glucose control which alters how your body burns energy. ​ Saxenda, and other GLP-1 agonists, help reduce glucagon levels while simultaneously reducing insulin resistance.

Both of these changes promote more normal blood glucose levels and help promote proper liver metabolism of glucose and help adipose tissue burn fat. ​ This is also why GLP-1 agonists are so helpful for patients with type II diabetes.

 

Glucagon is just as important (if not more important) in the regulation of glucose levels in the body.

Our current focus is on insulin and how it manages glucose levels and we generally completely ignore glucagon and its effects. But if you treat both insulin AND glucagon levels, you can get a much more normal glucose level and finally promote weight loss and fat burn.

  • Bottom line: Saxenda helps reduce hyperglucagonemia (lower glucagon levels) which promotes normal glucose metabolism in the body and in the liver. 

 

#4. Reduces Appetite

​Another benefit of using Saxenda is how it alters your appetite.

You’ve been conditioned to believe that your weight is the product of how many calories you burn minus the amount of calories you consume.

Conventional wisdom would have you believe that reducing your total calories will always result in weight loss, provided you burn more calories than you consume.

​Weight loss in general happens to be much more complex than this seriously oversimplified and inaccurate equation, but nonetheless here we are.

So here’s the deal with appetite and Saxenda.

One of the side effects of Saxenda is slight nauesa, and this is felt to occur due to how GLP-1 agonists alter gastric motility.

These medications slow down the gastrointestinal motility which means that your gastric contents empty more slowly.

This can result in symptoms such as reflux, and distention of the stomach which manifests as nausea.

Pretty much anything that tells your body that your stomach is full will also promote a reduction in appetite – this is natural and normal.

But, how does appetite impact weight loss?

Well, you do need some degree of calorie restriction to result in weight loss (but this should not be constant calorie restriction) and this calorie restriction from the loss in appetite is actually welcomed in this case.

 

The reason this appetite suppression is GOOD, is because it’s also accompanied by the accentuation of leptin levels.

What this means is that you can lose the weight by reducing your appetite, and instead of your body responding with increased leptin levels, the saxenda actually blocks that rise.

So you get the benefit of both worlds:

Appetite suppression that does NOT result in your weight being regained AND suppression of leptin levels at the same time.

THIS is why appetite suppression is good in this case. ​

 

  • Bottom line: Saxenda helps reduce appetite by slowing down gastric motility. This reduction in calories is also coupled with a reduction in leptin levels which results in weight loss over time. 

 

#5. Increases Metabolism

Saxenda also seems to have an effect on increasing your basal metabolic rate.

Your metabolism is probably one of the most important aspects involved in weight loss.

Why? Because your basal metabolic rate, or resting energy expenditure, is responsible for the MAJORITY of calories that you burn.

This metric is also responsible for how likely you are for keeping off any weight that you lose.

If you do any sort of diet that results in metabolic damaged (defined as reducing your metabolic rate) then your chances of regaining that weight back is VERY high.

This is famously illustrated in the biggest loser study which showed that contestants of this program suffered severe basal metabolic rate damage.

These contestants were burning on average 600-700 calories LESS per day than a normal person, which means that almost all of them gained the weight back that they lost.

 ​This is why most calorie restricted diets fail and why we, as a nation, have such a difficult time with weight loss.

​We put all of our focus on calories instead of on hormones and basal metabolic rate.

So how does Saxenda work?

Saxenda helps naturally improve your metabolism, probably through its effects on leptin levels.

Leptin feeds back to your hypothalamus and helps set your body set point – the amount of calories your body burns which in terms alters your appetite.

Your body is constantly trying to match the amount of calories your burn to the amount of calories that you consume. ​

 

  • Bottom line: Saxenda helps improve your metabolism over time, probably through its effects on leptin levels. 

 

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Saxenda vs Victoza

Liraglutide was originally developed to treat type II diabetes because it can help reduce insulin resistance, but was soon found to have a dramatic effect on weight.

Because of this the makers of Liraglutide (or Victoza as it is called if used to treat type II diabetes) came out with new name (saxenda) which is now FDA approved for weight loss. You might be confused about these two medications, so let explain the difference.

Let me be clear:

Saxenda and Victoza are the exact same medication, but they are a different thing.

Both medications use the same active ingredient which is Liraglutide.

Liraglutide is the reason that these medications both work.

Victoza is FDA approved for type II diabetes in the following dosages:

 

Saxenda is FDA ​approved for weight loss at the following dosages: 

 

You can see the main difference between the two is really just the dose and what they are approved to treat.

 

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How Saxenda® is taken

Inject your dose of Saxenda® under the skin (subcutaneous injection) in your stomach area (abdomen), upper leg (thigh), or upper arm, as instructed by your health care provider. Do not inject into a vein or muscle.

A once-daily, self-injectable medicine, Saxenda® comes in a prefilled pen.  It’s the first and only FDA-approved weight-loss medicine in a pen that helps you lose weight and keep it off.

The recommended adult starting dose of Saxenda is 0.6 mg daily injected subcutaneously (under the skin) on your stomach area (abdomen), upper thigh, or upper arm. It can be injected at any time of the day, without regard to meals. After one week, you may increase the dose to 1.2 mg once daily, gradually increasing the dose up to 3 mg daily. This gradual increase of the dose should minimize side effects on the digestive system.

Dose escalation schedule

Dose

Weeks

Dose escalation

4 weeks

0.6 mg

1st

1.2 mg

2nd

1.8 mg

3rd

2.4 mg

4th

Maintenance dose

3.0 mg

Saxenda is for subcutaneous use only. It must not be administered intravenously or intramuscularly.

Saxenda is administered once daily at any time, independent of meals. It should be injected in the abdomen, thigh or upper arm. The injection site and timing can be changed without dose adjustment. However, it is preferable that Saxenda is injected around the same time of the day, when the most convenient time of the day has been chosen.

Saxenda should not be mixed with other injectables (e.g. insulins).

If a dose is missed within 12 hours from when it is usually taken, the patient should take the dose as soon as possible. If there is less than 12 hours to the next dose, the patient should not take the missed dose and resume the once-daily regimen with the next scheduled dose. An extra dose or increase in dose should not be taken to make up for the missed dose.

 

Use the Saxenda® pen at home or on the go

Saxenda® is a once-daily, self-injectable medicine that comes in a pre-filled pen. Take your medicine each day at any time that is convenient for you, with or without food. Inject your dose under the skin (this is called subcutaneous injection) in your stomach area (abdomen), upper leg (thigh), or upper arm as instructed by your health care professional. Do not inject into a vein or muscle.

 

Do not use Saxenda® if

  • you or any of your family have a history of Medullary Thyroid Cancer
  • you or any of your family have a history of Multiple Endocrine Neoplasia
  • you are allergic to liraglutide or any of the ingredients in Saxenda®.
  • are under 18 years old
  • you are pregnant
  • you are breastfeeding
  • aged 75 years or more

 

What are the side effects?

Saxenda has no  influence on the ability to drive and use machines. But the following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

  • changed sense of taste
  • constipation
  • decreased appetite
  • diarrhea
  • dizziness
  • dry mouth
  • fatigue
  • gas
  • heartburn
  • mild abdominal pain or swelling
  • nausea
  • redness, itching, or swelling at the site of injection
  • vomiting

 

Price??

1 pen for $250 usd

1 box (5 pens) for $990 usd

Note: 1 pen last for 17 days

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